News and Highlights
Dr. Lawrence Casalino Co-Edits and Contributes Two Articles to Special Issue of Health Affairs
Lawrence P. Casalino, MD, PhD, MPH, the Livingston Farrand Associate Professor and Chief of the Division of Outcomes and Effectiveness Research, was one of the editors of a special issue of Health Affairs (May 2010), which had as its theme, “Reinventing Primary Care.” He also contributed two articles. The first was a commentary, “A Martian’s Prescription for Primary Care: Overhaul the Physician’s Workday.” This article was covered by MedPageToday.com and was featured in a blog on the Health Affairs website. He also co-authored an article titled “Higher Health Care Quality and Bigger Savings Found at Large Multispecialty Medical Groups.” The lead author of this article was Dr. William B. Weeks of the Dartmouth Institute for Health Policy and Clinical Practice and the lead author was Dr. Elliott S. Fisher, Director of the Dartmouth Institute’s Center for Healthcare Research and Reform. The other co-authors were Drs. Daniel Gottlieb, David Nyweide, Jason Sutherland, and Julie Bynum of the Dartmouth Institute, and Drs. Robin Gillies and Stephen Shortell of the University of California, Berkeley.
Dr. Lawrence Casalino Publishes Perspective in New England Journal of Medicine
Lawrence P. Casalino, MD, PhD, MPH, the Livingston Farrand Associate Professor and Chief of the Division of Outcomes and Effectiveness Research, was the lead author of an article in the New England Journal of Medicine titled “Specialist Physician Practices as Patient-Centered Medical Homes.” Co-authors included Drs. Robin R. Gillies and Stephen M. Shortell of the University of California, Berkeley, and Diane R. Rittenhouse of the University of California, San Francisco. The article discusses whether physician specialty practices could or should serve as patient-centered medical homes. As part of their analysis, the authors surveyed physician practices in several specialties to determine the percentage of their patients for whom they serve as primary care physicians. They conclude that specialists who want to serve as patient-centered medical homes should not be prevented from doing so, but they should be held to the same standards as primary-care-provider-based medical homes. These standards include providing first-contact, continuous and comprehensive care, and using systematic processes to improve the health of their patients. Read the medical college press release. The article was also covered by the website of the American Academy of Family Physicians.
Dr. Casalino Co-Authors Commentary in The Journal of the American Medical Association
Dr. Casalino was the senior author of an article in the May 5, 2010, issue of the Journal of the American Medical Association (JAMA) titled “Implementing Qualifications Criteria and Technical Assistance for Accountable Care Organizations.” The lead author was Stephen M. Shortell, PhD, MBA, MPH, of the Division of Health Policy and Management at University of California-Berkeley School of Public Health. The article discusses the types of health care delivery organizations that could potentially qualify as accountable care organizations as well as the assistance they would need to be successful.
Dr. April D. Kimmel Is Lead Author of Article in JAIDS
April D. Kimmel, PhD, MSc, Postdoctoral Associate in the Division of Health Policy, was the lead author of an article published in the July 1, 2010, issue of the Journal of Acquired Immune Deficiency Syndromes (JAIDS). Co-authors for the article, entitled “Laboratory Monitoring to Guide Switching Antiretroviral Therapy in Resource-Limited Settings: Clinical Benefits and Cost-Effectiveness,” included investigators from the Cost-Effectiveness of Preventing AIDS Complications (CEPAC) modeling group based at Massachusetts General Hospital in Boston along with collaborators from Côte d’Ivoire and France. The researchers used computer modeling to project life expectancy and costs of different strategies to guide antiretroviral therapy (ART) switching in HIV-infected patients in Côte d'Ivoire. They found that in resource-limited settings, CD4 count and HIV RNA monitoring to guide switching to second-line ART improve survival and, under most conditions, are cost-effective.
Dr. Mirella Salvatore Is Co-Author of Two Recent Articles
Mirella Salvatore, MD, Assistant Professor of Public Health in the Division of Community and Public Health Programs and Assistant Professor of Medicine in the Division of Infectious Diseases, co-authored two articles recently published in the journals Human Gene Therapy and Vaccine:
- Donatella RM Negri, Roberta Bona, Zuleika Michelini, Pasqualina Leone, Iole Macchia, Mary E Klotman, Mirella Salvatore and Andrea Cara. “Transduction of human antigen presenting cells with integrase defective lentiviral vector enables functional expansion of primed antigen specific CD8+ T cells.” Human Gene Therapy 2010 Mar 8. [Epub ahead of print]
- Dahlene Fusco, Xinyan Liu, Caroline Savage, Ying Taur, Weilie Xiao, Edward Kennelly, Jianda Yuan, Barrie Cassileth, Mirella Salvatore, and Genovefa Papanicolaou. “Echinacea Purpurea Aerial Extract Alters Course of Influenza Infection in Mice.” Vaccine 2010 Apr 9. [Epub ahead of print]
Dr. Linda Gerber Is Author of Three Recent Publications
Linda M. Gerber, PhD, Professor of Public Health in the Division of Biostatistics and Epidemiology and Professor of Epidemiology in Medicine, was an author of three recent publications:
- David Chiu, MD, Leif Peterson, PhD, Mitchell S.V. Elkind, MD, MS, Jonathan Rosand, MD, MSc, Linda M. Gerber, PhD, Marc D. Silverstein, MD, Glycine Antagonist in Neuroprotection(GAIN) Americas Trial Investigators. “Comparison of Outcomes after Intracerebral Hemorrhage and Ischemic Stroke.” Journal of Stroke and Cerebrovascular Diseases Volume 19, Issue 3, pages 225-229 (May 2010). Drs. Chiu, Peterson, and Silverstein were affiliated with the Methodist Hospital System of Weill Cornell Medical College in Houston, TX. Dr. Peterson also holds an appointment as Associate Professor of Public Health in the Division of Biostatistics and Epidemiology.
- Samuel J. Mann, MD, Linda M. Gerber, PhD. “Estimation of 24-hour sodium excretion from spot urine samples.” Journal of Clinical Hypertension (Greenwich) 2010 Mar;12(3):174-80. The study found that the sodium/creatinine ratio from a spot urine sample collected in the late afternoon/early evening at roughly the midpoint of a 24-hour collection, and adjusted for 24-hour creatinine excretion, strongly correlated with 24-hour sodium excretion. Additional studies are merited to further evaluate the role of the spot urine sample in assessing sodium intake.
- Samuel J. Mann, MD, Linda M. Gerber, PhD. “Estimation of 24-h Sodium Excretion From a Spot Urine Sample Using Chloride and Creatinine Dipsticks.” American Journal of Hypertension 2010 Mar 25. [Epub ahead of print] This study found that chloride and creatinine dipsticks appear to be promising as a convenient and inexpensive means to serially assess sodium excretion.
Recent Publications Co-Authored by Biostatistics and Epidemiology Faculty
Paul J. Christos, DrPH, MS, Lecturer in Public Health and Senior Research Biostatistician, was a co-author of three recently published articles. Madhu Mazumdar, PhD, MA, MS, Professor and Chief of the Division of Biostatistics and Epidemiology, was also a co-author on one of these:
- Gabriella Wernicke, M.D., Bhupesh Parashar, M.D., Fridon Kulidzhanov, Ph.D., Lillian Riley, B.A., Paul J. Christos, Dr.P.H., M.S., Andrew Fischer, M.D., Dattatreyudu Nori, M.D. and K. S. Clifford Chao, M.D. “Prospective Study Validating Inter- And Intraobserver Variability Of Tissue Compliance Meter In Breast Tissue Of Healthy Volunteers: Potential Implications For Patients With Radiation-Induced Fibrosis Of The Breast.” International Journal of Radiation Oncology*Biology*Physics 2010 Apr 13. [Epub ahead of print] The study found that the interobserver and intraobserver variability is small using tissue compliance meter (TCM) in healthy mammary tissue. A new prospective study will use TCM in women with breast cancer at risk of developing radiation-induced fibrosis (RIF) that may guide early detection, timely therapeutic intervention, and assessment of success of therapy for RIF.
- Heather K. Hamilton, Amy E. Rose, Paul J. Christos, Richard L. Shapiro, Russell S. Berman, Madhu Mazumdar, Michelle W. Ma, Daniel Krich, Leonard Liebes, Peter C. Brooksand Iman Osman. “Increased shedding of HU177 correlates with worse prognosis in primary melanoma.” Journal of Translational Medicine 2010; 8: 19. Published online 2010 February 23. The researchers conclude that further studies are warranted to determine the clinical utility of cryptic collagen epitope HU177 in risk stratification compared to the current standard of care. With the exception of Drs. Christos and Mazumdar, the authors are from NYU School of Medicine.
- E. Chuang, N. Wiener, P. Christos, R. Kessler, M. Cobham, D. Donovan, G. L. Goldberg, T. Caputo, A. Doyle, L. Vahdat & J. A. Sparano. “Phase I trial of ixabepilone plus pegylated liposomal doxorubicin in patients with adenocarcinoma of breast or ovary.” Annals of Oncology published online March 31, 2010. The study found that ixabepilone may be safely combined with pegylated liposomal doxorubicin, but tolerability is highly dependent upon the scheduling of both agents. This combination demonstrated efficacy in patients with breast and ovarian cancer and merits further evaluation in these settings.
Ashley Eggman Co-Authors Article on Patient Safety in the Cardiac Operating Room
Ashley A. Eggman, MS, Research Data Specialist in the Division of Health Policy, was a co-author of an article titled “Improving cardiac surgical care: A work systems approach,” published online March 2, 2010, in Applied Ergonomics. The goal of the paper was to provide an integrative review of specific work system factors in the OR that may directly impact surgical care processes, as well as the subsequent recommendations that have been put forth to improve surgical outcomes and patient safety. The lead author was Douglas A. Wiegmann of the Department of Industrial and Systems Engineering at the University of Wisconsin–Madison, and the senior author was Thoralf M. Sundt III of the Division of Cardiovascular Surgery, Mayo Clinic, Rochester, MN. Additional co-authors were Andrew W. ElBardissi of the Department of Surgery, Brigham and Women's Hospital, Harvard Medical School and Sarah Henrickson Parker of the University of Aberdeen in Scotland.
Dr. Ethan Basch Publishes Perspective in New England Journal of Medicine
Ethan Basch, MD, MSc, a medical oncologist at Memorial Sloan-Kettering Cancer Center and Assistant Professor of Public Health in the Division of Outcomes and Effectiveness Research, was the author of a Perspective published in the New England Journal of Medicine on March 11, 2010. Dr. Basch’s article was titled “The Missing Voice of Patients in Drug-Safety Reporting.” In it, he calls attention to the fact that the current drug-labeling practice for adverse events is based almost entirely on clinicians’ impressions of patients’ symptoms—not on patients’ own firsthand reports of their experiences with the drug. He discusses why and how this system should be changed.
Dr. Lawrence Scheier Authors Journal Article and Book Chapter
Lawrence M. Scheier, PhD, Associate Professor of Psychology in Public Health (Courtesy), was the lead author of an article published online April 27, 2010, in the Journal of Health Communication titled “Influence of a Nationwide Social Marketing Campaign on Adolescent Drug Use.” Dr. Scheier also wrote a chapter titled “Methods for Approximating Random Assignment: Regression Discontinuity and Propensity Scores,” in International Encyclopedia of Education, Volume 3 (Penelope Peterson, Eva Baker, Barry McGaw, [Editors], Oxford: Elsevier).
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